COL4A4 CLIA Kit for Human(Homo sapiens) | EIAab.comCOL4A4 CLIA Kit for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > COL4A4(Gene name) > Human

COL4A4 (Gene name),

Collagen alpha-4(IV) chain (Protein name ), CO4A4_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

COL4A4;

Protein name:

Collagen alpha-4(IV) chain;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. The alpha 3(IV) chain forms a triple helical protomer with alpha 4(IV) and alpha 5(IV); this triple helical structure dimerizes through NC1-NC1 domain interactions such that the alpha 3(IV), alpha 4(IV) and alpha 5(IV) chains of one protomer connect with the alpha 5(IV), alpha 4(IV) and alpha 3(IV) chains of the opposite protomer, respectively. Associates with LAMB2 at the neuromuscular junction and in GBM.

Function:

Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.

Subcellular Location:

Secreted extracellular space extracellular matrix basement membrane Colocalizes with COL4A4 and COL4A5 in GBM, tubular basement membrane (TBM) and synaptic basal lamina (BL).

Protein Attributes:

Sequence length:

1690

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1200:

1250:

1300:

1350:

1400:

1450:

1500:

1550:

1600:

1650:

1690:

WLTTVKADLQ | FSSAPAPDTL | KESQAQRQKI | SRCQVCVKYS |

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Hs.591645

String:

P53420

SMR:

P53420

MIM:

120131

Pfam:

PF01413

KEGG:

hsa:1286

STRING:

9606.ENSP00000379866

Uniprot:

P53420

FOR

ELISA Kit for Human Collagen alpha-4(IV) chain

Cat.:

E9534h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Collagen alpha-4(IV) chain

Cat.:

E9534m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Collagen alpha-4(IV) chain

Cat.:

E9534b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Collagen alpha-4(IV) chain

MSDS:

Please sign in first.

CLIA Kit for Human Collagen alpha-4(IV) chain

Cat.:

U9534b

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Collagen alpha-4(IV) chain

Cat.:

U9534m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Collagen alpha-4(IV) chain

MSDS:

Please sign in first.

CLIA Kit for Human Collagen alpha-4(IV) chain

Cat.:

U9534h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

Polyclonal Antibody for Human Collagen alpha-4(IV) chain

Cat.:

P9534Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Collagen alpha-4(IV) chain

Cat.:

P9534Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Collagen alpha-4(IV) chain

Protein for Human Collagen alpha-4(IV) chain

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Complete primary structure of the human type IV collagen alpha 4(IV) chain. Comparison with structure and expression of the other alpha (IV) chains."
Leinonen A. , Mariyama M. , Mochizuki T. , Tryggvason K. , Reeders S.T.
J. Biol. Chem.269:26172-26177(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;VARIANTS LEU-1004; MET-1327 AND PRO-1403
tissue: Kidney.
2.

"Determination of the genomic structure of the COL4A4 gene and of novel mutations causing autosomal recessive Alport syndrome."
Boye E. , Mollet G. , Forestier L. , Cohen-Solal L. , Heidet L. , Cochat P. , Gruenfeld J.-P. , Palcoux J.-B. , Gubler M.-C. , Antignac C.
Am. J. Hum. Genet.63:1329-1340(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS APSAR VAL-1030 AND LEU-1572;VARIANTS ALA-545; GLN-570; THR-931; LEU-1004; MET-1327; SER-1402 AND PRO-1403
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"Two genes, COL4A3 and COL4A4 coding for the human alpha3(IV) and alpha4(IV) collagen chains are arranged head-to-head on chromosome 2q36."
Momota R. , Sugimoto M. , Oohashi T. , Kigasawa K. , Yoshioka H. , Ninomiya Y.
FEBS Lett.424:11-16(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-23
5.

"cDNA isolation and partial gene structure of the human alpha 4(IV) collagen chain."
Sugimoto M. , Oohashi T. , Yoshioka H. , Matsuo N. , Ninomiya Y.
FEBS Lett.330:122-128(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1219-1690;VARIANTS MET-1327 AND PRO-1403
tissue: Eye.
6.

"Isolation and sequencing of cDNAs and genomic DNAs encoding the alpha 4 chain of basement membrane collagen type IV and assignment of the gene to the distal long arm of human chromosome 2."
Kamagata Y. , Mattei M.-G. , Ninomiya Y.
J. Biol. Chem.267:23753-23758(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1407-1507
7.

"Complete primary structure of the human alpha 3(IV) collagen chain. Coexpression of the alpha 3(IV) and alpha 4(IV) collagen chains in human tissues."
Mariyama M. , Leinonen A. , Mochizuki T. , Tryggvason K. , Reeders S.T.
J. Biol. Chem.269:23013-23017(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
8.

"Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains."
Borza D.B. , Bondar O. , Todd P. , Sundaramoorthy M. , Sado Y. , Ninomiya Y. , Hudson B.G.
J. Biol. Chem.277:40075-40083(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: HEXAMERIZATION
9.

"The clinical spectrum of type IV collagen mutations."
Lemmink H.H. , Schroeder C.H. , Monnens L.A.H. , Smeets H.J.M.
Hum. Mutat.9:477-499(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
10.

"Identification of mutations in the alpha 3(IV) and alpha 4(IV) collagen genes in autosomal recessive Alport syndrome."
Mochizuki T. , Lemmink H.H. , Mariyama M. , Antignac C. , Gubler M.-C. , Pirson Y. , Verellen-Dumoulin C. , Chan B. , Schroeder C.H. , Smeets H.J.M. , Reeders S.T.
Nat. Genet.8:77-82(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT APSAR SER-1201
11.

"Benign familial hematuria due to mutation of the type IV collagen alpha4 gene."
Lemmink H.H. , Nillesen W.N. , Mochizuki T. , Schroeder C.H. , Brunner H.G. , van Oost B.A. , Monnens L.A.H. , Smeets H.J.M.
J. Clin. Invest.98:1114-1118(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BFH GLU-897
12.

"Mutations in the COL4A4 and COL4A3 genes cause familial benign hematuria."
Badenas C. , Praga M. , Tazon B. , Heidet L. , Arrondel C. , Armengol A. , Andres A. , Morales E. , Camacho J.A. , Lens X. , Davila S. , Mila M. , Antignac C. , Darnell A. , Torra R.
J. Am. Soc. Nephrol.13:1248-1254(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BFH ARG-960;VARIANTS THR-6; SER-482 AND ALA-545
13.

"Mutations in the COL4A4 gene in thin basement membrane disease."
Buzza M. , Dagher H. , Wang Y.Y. , Wilson D. , Babon J.J. , Cotton R.G. , Savige J.
Kidney Int.63:447-453(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BFH GLU-116; ARG-960; GLU-999 AND LEU-1132;VARIANT SER-482

Product Feedback Wall

* Email:
*Comments: